Sunday, 12 January 2014

Why Does Wellbutrin Cause Weight Loss

Why Does Wellbutrin Cause Weight Loss

For some people, Wellbutrin can also cause weight gain. The short answer is that the dont really know for sure how it works and what effect it will have.

posted by SpecialK at 2:14 PM on July 20, 2007 1 favorite

Some people eat more when they are depressed, because food=comfort. Take wellbutrin, stop being depressed, eat less, exercise more as a result and, by the way, have more sexwellbutrin is good for that, too, and you lose weight.

Some people gain weight on wellbutrin because these are the people who DONT eat comfort food when they are depressed, the people who instead sleep a lot, or just dont eat. Once they feel better, they go back to their usual habits.

posted by misha at 2:21 PM on July 20, 2007

I think that Wellbutrin has a tendency to reduce addictive cravings in people, which is why it is also marketed as Zyban to help people stop smoking.

It also is one of the few ads that perks people up, whereas most of the common antidepressants make people kind of sleepy or lethargic. Being perky burns more calories than laying in bed staring at the ceilinig.

posted by tastybrains at 2:25 PM on July 20, 2007

When I was on Wellbutrin, it gave me lots of energy and dampened my appetite. This wore off after a few months, but it was nice to actually feel peppy after a year of depression.

posted by lychee at 2:55 PM on July 20, 2007

The true reason is not known, but bupropion is obviously known to inhibit DA reuptake. It has been speculated that elevating synaptic DA levels or agonizing DA receptors can cause weight loss.

The physiology of how DA is associated with weight loss is only partially understood, but there may be links to leptin and insulin, among many other factors.

posted by NucleophilicAttack at 3:10 PM on July 20, 2007

You might be interested in posted by docgonzo at 3:23 PM on July 20, 2007

Weight loss obviously isnt perfectly well understood, or wedve solved the problem of obesity by now. Which we havent, in case that wasnt obvious.

Theres a splendid color plate by Frank Netter illustrating the effect of hypothalamic lesions in the cat. Basically if you lesion in a pair of tiny nuclei extreme lateral in the hypothalamus, cats become anemic and placid; in the ventromedial area, however, lesions make the cat voracious and rageful. The hypothalamus exerts control, not only of mood and the appetitive functions in terms of behavior, but also influences metabolism by its connections with the pituitary; thyroid, cortisol and other steroids, insulin and insulinlike growth factors and growth hormones are all under direct regulatory control by the hypothalamus.

Unlike the average brain cell neuron that runs on glutamate or GABA, cells involved in these functions loosely termed limbic functions often use monoamines, which as far as you are concerned means dopamine, norepinephrine, or serotonin as neurotransmitters. The hypothalamus receives innervation from higher structures and itself contributes innervation to other brain structures in the various monoamine networks.

I wish I could show this plate and the other Netter hypothalamus illustrations to you as it would help clear this question up. If you chose to go to the library, you would find it in the last pages, as a supplement, to his spectacular CIBAGeigy illustrations of the anatomy of the nervous system.

This is necessarily a gloss; it would not be useful for me to start lecturing you, for example, on the functions of the ventral tegmental area and its connections to the basal forebrain nuclei because you have no context to place either of those brain structures. Also, I have only a rudimentary understanding of the knowledge in the field; as is probably unsurprising to you, there are people who make understanding the reasons for the answer to your question their lifes work.

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